Gabrilen, Ketoprofen, Voltaren, Diclofenac, Metacam, Meloxicam, Robenacoxib, Onsior,

comparison

I would like to compare the following drugs / preparations and discuss their application in the field of human and veterinary medicine.
Overview:
NSAIDs - painkillers

Non-steroidal anti-inflammatory drugs (NSAIDs) are analgesics with analgesic, antipyretic and anti-inflammatory properties. They are used for the treatment of pain, fever, inflammatory and degenerative diseases and for the prevention of cardiovascular events. The effects are due to the inhibition of prostaglandin synthesis by inhibition of cyclooxygenases.

The first active ingredient in this group was salicylic acid, later aspirin.

Chemical structure:

Anthranilic acid derivatives (e.g., mefenamic acid),

the (aryl) acetic acid derivatives (e.g., diclofenac),

the oxicams (e.g., piroxicam, meloxicam),

the propionic acid derivatives (e.g., ibuprofen, ketoprofen)

and the salicylates (e.g., acetylsalicylic acid).

NSAIDs are also called acid analgesics ?? because many are organic acids and typically contain a carboxy group (-COOH).

Ketoprofen, (Gabrilen,)
Ketoprofen is a non-steroidal anti-inflammatory drug from the group of propionic acid derivatives with analgesic and anti-inflammatory effect. The racemate ketoprofen is used exclusively externally to treat pain and inflammatory conditions of various causes.
Ketoprofen is a substituted benzophenone. This structural element is attributed to the local undesired effects. Ketoprofen was developed as an analogue of ibuprofen and is available as a racemate.
The effect is based on the inhibition of cyclooxygenase and the inhibition of the synthesis of prostaglandins.

Diclofenac, (Voltaren,)
Diclofenac is an active ingredient in the group of non-steroidal anti-inflammatory drugs with analgesic, antipyretic and anti-inflammatory properties. The effects are based on the inhibition of cyclooxygenase and thus the reduced prostaglandin synthesis. Diclofenac is used for the treatment of pain and inflammatory conditions of various causes.
Diclofenac is within the NSAR to the aryl acetic acid resp. the phenylacetic acid derivatives. Diclofenac has analgesic, antipyretic and anti-inflammatory properties. The effects are due to the inhibition of the enzyme cyclooxygenase and the reduced formation of the prostaglandins. Diclofenac has a short half-life of one to three hours and is therefore also administered in slow-release dosage forms. For the treatment of pain and inflammatory conditions of various causes, for example in arthritis, osteoarthritis,

Meloxicam, (metacam,)
Meloxicam is a non-steroidal anti-inflammatory drug from the group of oxicams with analgesic, antipyretic and anti-inflammatory properties. The drug is also used to treat arthritis and osteoarthritis. The effects are due to the inhibition of the synthesis of prostaglandins with a selectivity for COX-2. The tablets can be taken once a day during a meal due to the long half-life. As with other non-steroidal anti-inflammatories, serious side effects are possible. Meloxicam is metabolized by CYP2C9.

Robenacoxib (Onisior)
Robenacoxib is a member of the group of COX-2 inhibitors used in cats and dogs for the treatment of pain and inflammation of various causes. The effects are based on the selective inhibition of cyclooxygenase-2.